Aug 7 – 11, 2023
Novo Nordisk Fonden
Europe/Copenhagen timezone

Collective cell communication via intercellular force transmission

Aug 11, 2023, 1:45 PM
15m
Novo Nordisk Fonden

Novo Nordisk Fonden

Tuborg Havnevej 19, 2900 Hellerup

Speaker

Dr Siavash Monfared (NBI)

Description

The emergence of organization from the collective interactions of cells with no central guidance is a fundamental question in developmental biology, regeneration and biomedicine. Though widely studied from biochemistry and genetics perspectives, the interplay of mechanical interactions and the dynamics of self-organization remains elusive. In this talk, I will focus on the role of intercellular force transmission in three-dimensional, dense and squishy cell collectives. Using both a high-fidelity computational model and experimental data, I will show how altering local mechanical interactions at the single cell scale affects intercellular force transmission and order with consequences for biological functions: (1) cell extrusion program and (2) solid-to-fluid transition in active cell layers.

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