Dynamics of Stem Cell Decisions

28 Aug 2013, 09:30 → 30 Aug 2013, 18:00 Europe/Copenhagen

Auditorium A (Niels Bohr Institute)

Ala Trusina (Niels Bohr Institute), Anne Grapin-Botton, Josh Brickman, Kim Sneppen (Niels Bohr Institute), Lene Oddershede (Niels Bohr Institute), Mogens Høgh Jensen (Niels Bohr Institute)

Self-organization is an important concept from physics that emphasizes the emergence of complex patterns without detailed central plan. This meeting explores contemporary attempts to view cell differentiation in terms of self-organized systems. The meeting strives to encourage inspiring case stories for how individual and/or collective developmental decisions can be understood from simple rules for regulation within and communication between cells.

List of speakers:
Alfonso Martinez Arias, Cambridge
Erik Aurell, Stockholm
James Briscoe, London
Peter Buske, Leipzig
Eric M. Darling, Brown University
James Ferrell, Stanford
Jorge Ferrer, London
Albert Goldbeter, Bruxelles
Jochen Guck, Dresden
Kristian Helin, Copenhagen
Ryoichiro Kageyama, Kyoto
Sandeep Krishna, NCBS, Bangalore
Sally Lowell, Edinburgh
Jenny Nichols, Cambridge
Ertugrul Ozbudak, Einstein, NY
Lykke Pedersen, Copenhagen
Carsten Peterson, Lund
Oliver Pourquie, Strasbourg
Tristan Rodriguez, London
Henrik Semb, Copenhagen
Palle Serup, Copenhagen
Timm Schroeder, ETH Zurich
Benny Shilo, Weizmann, Rehovot
Jose Silva, Cambridge
Genevieve Thon, Copenhagen

Paper Map,_hotels13.pdf

Poster Poster_(2).pdf

Wednesday, 28 August

09:30 → 10:30 Networks, Non coding RNA and Chromatin

09:30 Kristian Helin

Role of Epigenetic regulators in stem cells, differentiation and cancer

10:00 Genevieve Thon

Establishment of heterochromatin domains

10:30 → 11:00 Coffee

Coffee break

11:00 → 12:30 Networks, Non coding RNA and Chromatin

11:00 Sandeep Krishna

Counting genomes: the lysis-lysogeny decision in temperate bacteriophage

11:30 Erik Aurell

Lognormality and oscillations in the coverage of high-throughput transcriptomic data towards gene ends

12:00 Jorge Ferrer

Epigenomic regulation of the developing pancreas

12:30 → 14:30 Lunch

14:30 → 16:00 Networks, Heterogeneity and Pluripotency

14:30 Alfonso Martinez Arias

Wnt signalling, heterogeneities in gene expression and the (meta)stability of the pluripotent state

15:00 Carsten Peterson

Transcriptional regulation of lineage commitment - a stochastic model of cell fate decisions

15:30 Jose Silva

Towards understanding induced pluripotency

16:00 → 17:00 Coffee & Poster Session

17:00 → 18:20 Networks, Heterogeneity and Pluripotency

17:00 Tim Schroeder

Long-term quantitative single cell imaging: New tools for old questions

17:30 Jenny Nichols

Characterising the specification of pluripotency during early mouse development and ES cell isolation

18:00 Kevin Chalut

Pre-committed state of embryonic stem cells defined by an auxetic nucleus

18:30 → 20:00 Dinner

Thursday, 29 August

09:15 → 10:15 Mechanics of Renewal and Differentiation

09:15 Eric Darling

Predicting stem cell differentiation through mechanics

09:45 Jochen Guck

The function-specific evolution of cell and nuclear mechanics during differentiation

10:15 → 11:15 Coffee

11:15 → 12:45 Mechanics of Renewal and Differentiation

11:15 Peter Buske

From predetermination to self organization - Modelling the intestinal crypt

11:45 Evan Manuel Figueiredo-Larsen

Acquisition of heterogeneity assessed by single-cell profiling in self-organizing pancreatic organoids grown in 3D

12:00 Sally Lowell

Too many choices? Variability and unpredictability during differentiation of pluripotent cells

12:30 Elke Ober

Cell communication and organ bud morphogenesis

12:45 → 14:30 Lunch

14:30 → 16:00 Oscillations

14:30 Olivier Pourquie

The vertebrate segmentation clock

15:00 Albert Goldbeter

From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle

15:30 Ertugrul Ozbudak

Systems-level analysis of the vertebrate segmentation clock

16:00 → 17:00 Coffee & Poster Session

17:00 → 18:30 Oscillations

17:00 Ryoichiro Kageyama

Oscillatory gene expression in somitogenesis and neurogenesis

17:30 Palle Serup

Multiple functions of Notch and Hes1 in pancreas development

18:00 Lykke Pedersen

Modeling of the Wnt pathway during segmentation

18:30 → 20:00 Dinner

Friday, 30 August

09:30 → 10:30 Signalling

09:30 Benny Shilo

Patterning the embryonic DV axis by self-organized shuttling

10:00 Jim Ferrell

Bistability and Trigger Waves in Mitosis

10:30 → 11:30 Coffee

11:30 → 13:00 Signalling

11:30 Tristan Rodriquez

12:00 Henrik Semb

12:30 James Briscoe

The Gene Regulatory Logic for Sonic Hedgehog Morphogen Interpretation

13:00 → 15:00 Lunch

15:00 → 17:00 Departure